Napoli give Andre Frank Zambo Anguissa his first begin since November, as Alisson Santos helps Rasmus Hojlund towards unpredictable Lecce.
It kicks off at at 17.00 GMT (18.00 CET).
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The Partenopei have the chance to consolidate third place after slender and hard-fought 2-1 wins over Verona and Torino.
Antonio Conte has but extra additions to the harm checklist, and Juan Jesus, with Stanislav Lobotka, David Neres, Giovanni Di Lorenzo and Amir Rrahmani already out.
Scott McTominay has been again in coaching since Tuesday and subsequently will get a spot on the bench together with Kevin De Bruyne and Romelu Lukaku, each recovering from long-term accidents.
NAPLES, ITALY – JANUARY 17: Scott McTominay of SSC Napoli battles for possession with Aster Vranckx of US Sassuolo Calcio through the Serie A match between SSC Napoli and US Sassuolo Calcio at Stadio Diego Armando Maradona on January 17, 2026 in Naples, Italy. (Picture by Francesco Pecoraro/Getty Photographs)
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Lecce earned a probably essential 2-1 victory over Cremonese to pull them out of the underside 4.
Omri Gandelman has shaken off a knee downside, however Medon Berisha, Francesco Camarda and Kialonda Gaspar are out of motion.
Nikola Stulic leads the assault with Lameck Banda, whereas Napoli-owned Walid Cheddira is on the bench.
LECCE, ITALY – JANUARY 11: Nikola Stulic of US Lecce celebrates after scoring his staff’s opening objective through the Serie A match between US Lecce and Parma Calcio 1913 at Stadio Through del Mare on January 11, 2026 in Lecce, Italy. (Picture by Maurizio Lagana/Getty Photographs)
Napoli vs. Lecce line-ups
Napoli: Meret; Beukema, Buongiorno, Olivera; Politano, Anguissa, Gilmour, Spinazzola; Elmas, Alisson Santos; Hojlund
Lecce: Falcone; Danilo Veiga, Siebert, Tiago Gabriel, Gallo; Coulibaly, Ramadani; Pierotti, Ngom, Banda; Stulic
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